Manufacturing & Packaging

Experts in pharmaceutical manufacturing Technologies

TAGEN PHARMACEUTICALS has substantial expertise in commercial manufacturing of conventional dosage forms but also in specialist pharmaceutical technologies such as modified release pellets and in products requiring containment areas including hormones, penicillins, cephalosporins and controlled drugs.

Packaging

All types of manufactured products can be packaged, allowing customers to outsource parts or their full supply chain to Tagen pharmaceuticals.

With a high level of customer service and quality, accurate documentation and on-time delivery, Tagen pharmaceuticals allows its customers to efficiently manage their market supplies.

Primary and secondary packaging: a key component of our services

Formulation development

Tagen pharmaceuticals provides pre-formulation evaluation and formulation development services for conventional oral solids, semi-solids and liquids as well as products requiring dedicated containment such as:

  • Hormones (oral and topical)
  • Antibiotics (oral) including penicillins and cephalosporins
  • Controlled drugs

    • Pre-formulation evaluation services include:

    • pKa determination
    • Partition coefficient
    • Chemical stability profile
    • Solubility determination
    • Crystal properties and polymorphism (DSC, XRPD)

Formulation development capabilities include:

DOSAGE FORM AVAILABLE FORMS CHARACTERISTICS OTHER FEATURES
Solid Dosage Tablets Uncoated
Film coated
Effervescent
Capsules Hard capsules  
Pellet Immediate release
Extended release
Gastric-resistant release
 
Powder Non-sterile  
Semi-solid Dosage Ointments Non-sterile  
Creams Non-sterile  
Gels Non-sterile  
Suppositories    
Liquid Dosage Solutions Non-sterile (oral and topical) Aqueous or solvent based
Emulsions Non-sterile (oral and topical) Aqueous or solvent based
Suspensions Non-sterile (oral and topical) Aqueous or solvent based

Clinical Batch Manufacture

  • Manufacturing of IMPs (solids, semi-solids and liquids) and matching placebos
  • De-blistering and de-packaging of medication
  • Blinding/ manufacturing of capsules (semi-automatically)
  • Over-encapsulation (capsule sizes: 5 – 000 and E – AAA)
  • Single tablet/ capsule in a capsule
  • 1/2 tablet in a capsule
  • Multiple tablets/ capsules in a capsule
  • Available Modu-C filling stations
  • Dosator for powder/ granules
  • Blinding/ manufacturing of capsules (automatically) with Modu-C capsule filling machine.
  • Pellet dosing by volumetric principle starting at a dosing range of > 50 mg.
  • Format-free tablet/ capsule dosing
  • Micro tablet dosing with 100 % camera control system on shape, colour of micro tablets
  • Further filling stations available on request
  • 100% online and offline weight and tare/ gross weight check

Scale up and process validation

Tagen pharmaceuticals offers pharmaceutical formulation development and subsequent scale-up services to ensure safe routine production at commercial scale.

Batch sizes are adapted to meet customers' requirements. For each production step, qualified equipment is available in the relevant dimensions to support the processing across a range of batch sizes, providing customers with a consistent and reliable scale-up service.

Process validation, including complete documentation, is performed on the first product batches and according to customer requirements. Validation will qualify the manufacturing process in respect of product conformity with specifications.

    At pilot and commercial scale, dedicated containment areas enable us to handle specific product types, including:

  • Hormones (oral and topical)
  • Steroids (oral and topical)
  • Antibiotics (oral), including penicillins and cephalosporins
  • Controlled drugs

Solids

  • Blister packs
  • Tubes for chewable and effervescent tablets
  • Sachets
  • Glass or plastic bottles for dry
  • suspension
  • Glass or plastic bottles for tablets and capsules
  • Tamper-proof seals
  • Flow packs (blistered sachets)
  • Labelling and cartoning of pouches

Liquids

  • Glass or plastic bottles
  • Pump sprays
  • Pressurised sprays
  • Ampoules
  • Stick packs
  • Secondary packaging

Semi-Solids

  • Aluminium tubes
  • Plastic and laminated tubes
  • Glass and plastic bottles including pumps
  • Suppositories
  • Stick packs
  • Secondary packaging